Thi Diep Hoang and Le Sy Vinh and Tomas Flouri and Alexandros Stamatakis and Arndt von Haeseler and Bui Quang Minh (2016) A new phylogenetic tree sampling method for maximum parsimony bootstrapping and proof-of-concept implementation. In: 2016 Eighth International Conference on Knowledge and Systems Engineering (KSE).
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Official URL: http://doi.org/10.1109/KSE.2016.7758020
Reconstructing maximum parsimony (MP) trees along with bootstrap for large multiple sequence alignments is a computationally challenging task. In this paper, we present MPBoot, a new method for approximating MP bootstrap based on the idea of a previously introduced method for maximum likelihood bootstrap. MPBoot economizes the computations by only sampling trees on the original alignment and simultaneously calculating exact parsimony scores for all bootstrap alignments. Preliminary experiments on simulated data showed that MPBoot is about 2-3.5 times faster and yields better parsimony scores than a fast bootstrap procedure implemented in TNT. MPBoot also produced less biased support value than TNT for small simulated data sets (<;= 200 sequences). However, for large number of sequences (>=500) MPBoot overestimates the probability that a clade is true, i.e., results in likely high false positive rates. As MPBoot is currently a proof-of-concept implementation, more work is to understand the limitations of the method.
|Item Type:||Conference or Workshop Item (Paper)|
|Subjects:||Information Technology (IT)|
|Divisions:||Faculty of Information Technology (FIT)|
|Deposited By:||Ms. Diep/T Hoang|
|Deposited On:||29 Dec 2016 08:22|
|Last Modified:||29 Dec 2016 08:22|
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