VNU-UET Repository: No conditions. Results ordered -Date Deposited. 2024-03-29T09:51:33ZEPrintshttp://eprints.uet.vnu.edu.vn/images/sitelogo.pnghttps://eprints.uet.vnu.edu.vn/eprints/2018-12-17T03:58:20Z2018-12-17T03:58:21Zhttp://eprints.uet.vnu.edu.vn/eprints/id/eprint/3258This item is in the repository with the URL: http://eprints.uet.vnu.edu.vn/eprints/id/eprint/32582018-12-17T03:58:20ZNovel Apparatus for Simultaneous Monitoring of Electrocardiogram in Awake ZebrafishThis paper reports polymer-based apparatus with embedded flexible thin-film electrodes to monitor electrocardiogram (ECG) of zebrafish under mild or zero anesthesia. The apparatus were made of polydimethylsiloxane (PDMS) using the molding technique with molds formed by 3D printing. The system is capable of acquiring intrinsic ECG from multiple fish simultaneously, thus introducing a novel method to phenotypically assess the hearts’ functionalities, supporting heart regeneration studies, drug screening and other related bioinvestigations using the zebrafish model. Smart algorithms were developed to facilitate data processing and analyses. The recorded ECG was compared with that of the same fish under full sedation and a proof-of-concept 4-chamber system was demonstrated. The process does not require a cleanroom, therefore being cost effective and holding promise to accelerate numerous studies in various disciplines using the zebrafish modelThi Thanh Van Nguyenvanntt@vnu.edu.vnNhu Chi Trantrannhuchi@vnu.edu.vnThanh Tung Buitungbt@vnu.edu.vnDuc Trinh Chutrinhcd@vnu.edu.vnAng SherpaMichael LenningPaul MarshNick GarzonPeter HofsteenHung Caohungcao@uw.eduJingchun YangXiaolei Xu2017-12-05T06:27:06Z2017-12-05T06:27:06Zhttp://eprints.uet.vnu.edu.vn/eprints/id/eprint/2740This item is in the repository with the URL: http://eprints.uet.vnu.edu.vn/eprints/id/eprint/27402017-12-05T06:27:06ZNovel Apparatus for Simultaneous Monitoring of
Electrocardiogram in Awake ZebrafishThis paper reports polymer-based apparatus with embedded flexible thin-film electrodes to monitor electrocardiogram (ECG) of zebrafish under mild or zero anesthesia. The apparatus were made of polydimethylsiloxane(PDMS) using the molding technique with molds formed by 3D printing. The system is capable of acquiring intrinsic ECG from multiple fish simultaneously, thus introducing a novel method to phenotypically assess the hearts’ functionalities, supporting heart regeneration studies, drug screening and other related bio-investigations using the zebrafish model. Smart algorithms were developed to facilitate data processing and analyses. The recorded ECG was compared with that of the same fish under full sedation and a proof-of-concept 4-chamber system was demonstrated. The process does not require a cleanroom, therefore being cost effective and holding promise to accelerate numerous studies in various disciplines using the zebrafish model.Ang SherpaDaniel SchossowMichael LenningPaul MarshNick GarzonPeter HofsteenHung CaoJingchun YangXiaolei XuThi Thanh Van Nguyenvanntt@vnu.edu.vnNhu Chi Trantrannhuchi@gmail.comThanh Tung Buitungbt@vnu.edu.vnDuc Trinh Chutrinhcd@vnu.edu.vn