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Preparation and characterization of niosome encapsulated curcumin

Le, Thi Hien and Nguyen, Thi Yen and Tuong, Van Thuan and Tran, Thi Hai Yen and Vu, Thi Huyen (2017) Preparation and characterization of niosome encapsulated curcumin. In: The 2nd International Conference On Pharmacy Education and Research Network of ASEAN, 21-22 November 2017, Kuala Lumpur.

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Niosome encapsulated curcumin were prepared by ethanol injection method with continuous ethanol evaporation using non-ionic surfactant span 80, cholesterol and curcumin. Curcumin-niosomes were purified from unencapsulated curcumin and impurities by size exclusion chromatography. Field emission scanning electron microscopy (FE-SEM) demonstrated that curcumin-niosomes had relatively uniform, spherical shapes with estimated diameters of 50 nm. Dynamic light scattering (DLS) analysis indicated that the size of particles hardly depended on the solvent evaporation time. Niosomal encapsulation efficiency of curcumin (EE), which was determined by fluorospectrometer, incredibly increased after 2-hour ethanol evaporation. It reached the highest value of 98% after 5 hours of ethanol evaporation for the mixture of span80, cholesterol, curcumin in a molar ratio of 45: 30: 1.

Item Type: Conference or Workshop Item (Paper)
Subjects: Engineering Physics
Divisions: Faculty of Engineering Physics and Nanotechnology (FEPN)
Depositing User: Hien Thi Le
Date Deposited: 29 Nov 2017 03:49
Last Modified: 29 Nov 2017 03:49

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