%A Ngoc Thang Bui
%J Computer Science
%T A Novel Framework to Improve siRNA Efficacy Prediction
%X Short interfering RNA sequences (siRNAs) can knockdown target genes and thus have an immense impact on biology and pharmacy research. The key question of which siRNAs have high knockdown ability in siRNA research remains challenging as current known results are still far from expectation. This work aims to develop a generic framework to enhance siRNA knockdown efficacy prediction. The key idea is first to enrich siRNA sequences by incorporating them with rules found for designing effective siRNAs and representing them as transformed matrices, then to employ the bilinear tensor regression to do prediction on those matrices. Experiments show that the proposed method achieves results better than existing models in most cases.
%P 400-412
%V 8444
%D 2014
%C Taiwan
%L SisLab1190