eprintid: 1688
rev_number: 10
eprint_status: archive
userid: 12
dir: disk0/00/00/16/88
datestamp: 2016-05-27 05:10:13
lastmod: 2016-05-27 05:12:39
status_changed: 2016-05-27 05:10:13
type: article
metadata_visibility: show
creators_name: Nguyen, Tien Anh
creators_name: Tran, Duc Tan
creators_name: Pliquett, U.
creators_name: Urban, G.A.
creators_id: anhnt007@gmail.com
creators_id: tantd@vnu.edu.vn
creators_id: Pliquett@gmail.com
creators_id: Urban@gmail.com
title: Behavior and the Response of Cancer Cells on Anticancer Drug Treatment Monitored with Microelectrode Array
ispublished: pub
subjects: ECE
subjects: ElectronicsandComputerEngineering
divisions: fac_fet
abstract: A cell-based impedance biosensor using microelectrode array has been developed for monitoring cellular activities of MCF-7 breast cancer cells and evaluating drug-induced apoptosis. Using this device, different activities of cells such as cell attachment, adhesion, and spreading are monitored by measuring impedance spectra and interpreting the data using an electrical equivalent circuit. In order to demonstrate pharmaceutical relevance, the cells were treated with 25 μM of anti-cancer drug Cisplatin. It was found that cell spreading caused a significant increase of impedance magnitude in the frequency range between 10 kHz and 100 kHz during 23 h of incubation, which is reversed after 24 h treatment with Cisplatin. This reversal is attributed to cell apoptosis, which is confirmed by microscopic observation of the cells.
date: 2015
date_type: published
publisher: Elsevier
full_text_status: public
publication: Procedia Engineering
volume: 120
pagerange: 928-931
refereed: TRUE
issn: 1877-7058
citation:   Nguyen, Tien Anh and Tran, Duc Tan and Pliquett, U. and Urban, G.A.  (2015) Behavior and the Response of Cancer Cells on Anticancer Drug Treatment Monitored with Microelectrode Array.  Procedia Engineering, 120 .   pp. 928-931.  ISSN 1877-7058     
document_url: https://eprints.uet.vnu.edu.vn/eprints/id/eprint/1688/1/1-s2.0-S1877705815024649-main.pdf