eprintid: 1826
rev_number: 8
eprint_status: archive
userid: 12
dir: disk0/00/00/18/26
datestamp: 2016-07-22 03:40:20
lastmod: 2016-07-22 03:40:20
status_changed: 2016-07-22 03:40:20
type: conference_item
metadata_visibility: show
creators_name: Nguyen Tien, Anh
creators_name: Nguyen Van, Tien
creators_name: Tran Duc, Tan
creators_name: Nguyen Van, Toan
creators_name: Le Chi, Hieu
creators_name: Le Hoai, Quoc
creators_id: tantd@vnu.edu.vn
title: Microfluidic Impedance Biosensors For Monitoring A Single And Multiple Cancer Cells In Anticancer Drug Treatments
ispublished: pub
subjects: ElectronicsandComputerEngineering
divisions: fac_fet
abstract: In this work, we present a novel microfluidic impedance biosensor chip for trapping both a single and multiple cancer cells and monitoring their response to the anticancer drug treatment. By designing different sizes of working microelectrodes together with the V-shaped cell capture structures, a single or multiple cells are trapped on the microelectrodes surfaces. In addition, by utilizing the passive pumping method, cells can be trapped and positioned inside the microchannels without the need of using the outer micro pump or syringe. The impedance change induced by the response of cells to the anticancer drug Cisplatin treatment was successfully recorded. The proposed biosensor chip has a great potential for applications in cancer cell research, drug screening, and quantification of cancer cells from various tumor stages. The results of this study open potential research collaborations about development of cost-effective devices and lab-on-chips for early disease detection , studies of cancerous cells and their response to anti-cancer drugs to optimize cancer treatments, charac-terisation of mechanical properties of cells, new drug delivery mechanisms, and micro and nano manufacturing .
date: 2016-06-26
date_type: published
official_url: http://csc.hcmiu.edu.vn/bmeconf/bme2016/
full_text_status: public
pres_type: paper
pagerange: 124-127
event_title: 6th International Conference on the Development of Biomedical Engineering in Vietnam
event_type: conference
refereed: TRUE
citation:   Nguyen Tien, Anh and Nguyen Van, Tien and Tran Duc, Tan and Nguyen Van, Toan and Le Chi, Hieu and Le Hoai, Quoc  (2016) Microfluidic Impedance Biosensors For Monitoring A Single And Multiple Cancer Cells In Anticancer Drug Treatments.  In: 6th International Conference on the Development of Biomedical Engineering in Vietnam.     
document_url: https://eprints.uet.vnu.edu.vn/eprints/id/eprint/1826/1/bai1_tienanh.pdf