eprintid: 2318
rev_number: 7
eprint_status: archive
userid: 270
dir: disk0/00/00/23/18
datestamp: 2016-12-28 14:56:03
lastmod: 2016-12-28 14:56:03
status_changed: 2016-12-28 14:56:03
type: conference_item
metadata_visibility: show
creators_name: Tran, T. T. H.
creators_name: Nguyen, N. V.
creators_name: Nguyen, N.C.
creators_name: Bui, Thanh Tung
creators_name: Chu, Duc Trinh
creators_id: tungbt@vnu.edu.vn
creators_id: trinhcd@vnu.edu.vn
title: Biological microparticles detection based on differential capacitive sensing and dielectrophoresis manipulation
ispublished: pub
subjects: ECE
divisions: fac_fet
keywords: capacitance, Capacitive sensor, cell manipulation, Cells (biology), DC4D, Dielectrophoresis, electric fields, Electrodes, HeLa cell, permittivity, Sensors
abstract: The manipulation and detection of living cells are essential requirements for many applications in biology, biotecnology and medicine. In this study, we propose a microfluidic device, which facilitated of a differential capacitively coupled contactless conductively detection (DC4D) coplanar capacitor structure and a dielectrophoresis (DEP) concentrator based on circular electrodes for detecting of living cells. With the proposed device, first, the target and non-target cells are guided toward the center of the working chamber due to the dielectrophoresis forces. Then the target cells are captured by the electrode covered with aptamers, which possess a high affinity to the target cells. After being flushed to wash away the non-target cells in the working chamber, the differential capacitance is read to identify the presence of target cells. Numerical simulations of the DEP manipulation and DC4D were performed to proof the concept of the proposed design. A prototype of the proposed device was fabricated using micromachining technology. Manipulation and sensing performances of the device were investigated. The evaluation results show that the capacitance output changes up to 3fF corresponding to the presence of about twenty-five cells captured at the electrode.
date: 2016-10
date_type: published
full_text_status: none
pres_type: lecture
pagerange: 297-301
event_title: 2016 International Conference on Advanced Technologies for Communications (ATC)
event_dates: 2016
event_type: conference
refereed: TRUE
citation:   Tran, T. T. H. and Nguyen, N. V. and Nguyen, N.C. and Bui, Thanh Tung and Chu, Duc Trinh  (2016) Biological microparticles detection based on differential capacitive sensing and dielectrophoresis manipulation.  In: 2016 International Conference on Advanced Technologies for Communications (ATC), 2016.