@inproceedings{SisLab2610,
       booktitle = {H?I NGH{\d I} V?T L{\'Y} CH?T R?N V{\`A} KHOA H{\d O}C V?T LI?U TO{\`A}N QU?C L?N TH? 10 (SPMS 2017)},
           month = {October},
           title = {Nghi{\^e}n c?u b{\`a}o ch? niosome l{\`a}m h? mang thu?c nano ?ng d{\d u}ng cho indomethacine},
          author = {Thi Hien Le and Hong Nhung Luong and Thi Yen Nguyen and Van Thuan Tuong and Thi Hai Yen Tran},
            year = {2017},
           pages = {760--763},
             url = {https://eprints.uet.vnu.edu.vn/eprints/id/eprint/2610/},
        abstract = {M?t trong nh?ng h??ng ph{\'a}t tri?n m{\d a}nh c{\h u}a c{\^o}ng ngh? nano sinh h{\d o}c l{\`a} nghi{\^e}n c?u ch? t{\d a}o v{\`a} ?ng d{\d u}ng c{\'a}c ch?t mang nano (nanocarier) {\dj}? ph{\^a}n ph?i c{\'a}c ch?t c{\'o} ho{\d a}t t{\'i}nh sinh h{\d o}c v?i m{\d u}c {\dj}{\'i}ch t{\u a}ng t{\'i}nh sinh kh{\h a} d{\d u}ng c{\h u}a ch{\'u}ng. Niosome l{\`a} m?t d{\d a}ng ti?u ph{\^a}n nano mang thu?c c{\'o} c?u tr{\'u}c d{\d a}ng t{\'u}i v?i nh{\^a}n b{\^e}n trong l{\`a} m?t khoang ch?a n??c v{\`a} l?p v{\h o} l{\`a} m{\`a}ng k{\'e}p ch?t ho{\d a}t {\dj}?ng b? m?t kh{\^o}ng mang {\dj}i?n. Indomethacin l{\`a} thu?c kh{\'a}ng vi{\^e}m kh{\^o}ng steroid d{\`u}ng {\dj}? {\dj}i?u tr{\d i} c{\'a}c b?nh v? c? x??ng kh?p. Do indomethacin {\'i}t tan trong n??c, {\dj}? th?m th?u qua da kh{\^o}ng cao v{\`a} c{\'o} th? g{\^a}y k{\'i}ch ?ng v?i da, n{\^e}n {\dj}{\'o}ng g{\'o}i indomethacine b?ng niosome s{\~e} g{\'o}p ph?n c{\h a}i thi?n c{\'a}c h{\d a}n ch? c{\h u}a thu?c n{\`a}y khi b{\^o}i ngo{\`a}i da. Niosome-indomethacine {\dj}??c t{\d a}o th{\`a}nh b?ng ph??ng ph{\'a}p ti{\^e}m ethanol t? c{\'a}c t{\'a} d??c span 80, cholesterol v{\`a} d??c ch?t indomethacin ? nhi?t {\dj}? 65?, sau {\dj}{\'o} {\dj}??c tinh s{\d a}ch b?ng k{\~y} thu?t s?c k{\'y} l{\d o}c gel. Th{\`a}nh ph?n h{\'o}a h{\d o}c ti?u ph{\^a}n {\dj}??c x{\'a}c {\dj}{\d i}nh b?ng ph? h?ng ngo{\d a}i bi?n {\dj}?i chu?i Fourier (FTIR). {\h A}nh ch{\d u}p b?ng k{\'i}nh hi?n vi {\dj}i?n t? qu{\'e}t ph{\'a}t x{\d a} tr??ng (FESEM) cho th?y ti?u ph{\^a}n niosome-indomethacin c{\'o} d{\d a}ng h{\`i}nh c?u v{\`a} k{\'i}ch th??c t??ng {\dj}?i {\dj}?ng {\dj}?u kho{\h a}ng 50 nm. Ph??ng ph{\'a}p ph{\^a}n t{\'i}ch ph? h?p th{\d u} UV-vis cho th?y hi?u su?t n{\d a}p thu?c {\dj}{\d a}t t?i {\dj}a 97\% sau 1 gi? ch? t{\d a}o v?i t{\h i} l? s? mol span 80: cholesterol: indomethacin l{\`a} 60: 40: 4.5.}
}