%A Thi Hien Le
%A Thi Yen Nguyen
%A Van Thuan Tuong
%A Thi Hai Yen Tran
%A Thi Huyen Vu
%J ASEAN Pharmnet 2017 proceedings
%T Preparation and characterization of niosome encapsulated curcumin
%X Niosome encapsulated curcumin were prepared by ethanol injection method with continuous ethanol evaporation using non-ionic surfactant span 80, cholesterol and curcumin. Curcumin-niosomes were purified from unencapsulated curcumin and impurities by size exclusion chromatography. Field emission scanning electron microscopy (FE-SEM) demonstrated that curcumin-niosomes had relatively uniform, spherical shapes with estimated diameters of 50 nm. Dynamic light scattering (DLS) analysis indicated that the size of particles hardly depended on the solvent evaporation time. Niosomal encapsulation efficiency of curcumin (EE), which was determined by fluorospectrometer, incredibly increased after 2-hour ethanol evaporation. It reached the highest value of 98% after 5 hours of ethanol evaporation for the mixture of span80, cholesterol, curcumin in a molar ratio of 45: 30: 1.
%P 208-214
%D 2017
%C Kuala Lumpur
%L SisLab2680