TY  - CONF
ID  - SisLab2740
UR  - https://eprints.uet.vnu.edu.vn/eprints/id/eprint/2740/
A1  - Sherpa, Ang
A1  - Schossow, Daniel
A1  - Lenning, Michael
A1  - Marsh, Paul
A1  - Garzon, Nick
A1  - Hofsteen, Peter
A1  - Cao, Hung
A1  - Yang, Jingchun
A1  - Xu, Xiaolei
A1  - Nguyen, Thi Thanh Van
A1  - Tran, Nhu Chi
A1  - Bui, Thanh Tung
A1  - Chu, Duc Trinh
Y1  - 2017/10/30/
N2  - This paper reports polymer-based apparatus with embedded flexible thin-film electrodes to monitor electrocardiogram (ECG) of zebrafish under mild or zero anesthesia. The apparatus were made of polydimethylsiloxane(PDMS) using the molding technique with molds formed by 3D printing. The system is capable of acquiring intrinsic ECG from multiple fish simultaneously, thus introducing a novel method to phenotypically assess the hearts? functionalities, supporting heart regeneration studies, drug screening and other related bio-investigations using the zebrafish model. Smart algorithms were developed to facilitate data processing and analyses. The recorded ECG was compared with that of the same fish under full sedation and a proof-of-concept 4-chamber system was demonstrated. The process does not require a cleanroom, therefore being cost effective and holding promise to accelerate numerous studies in various disciplines using the zebrafish model.
TI  - Novel Apparatus for Simultaneous Monitoring of
Electrocardiogram in Awake Zebrafish
SP  - 1434
M2  - Glasgow, UK
AV  - none
EP  - 1436
T2  - IEEE Sensors 2017
ER  -