eprintid: 2740
rev_number: 10
eprint_status: archive
userid: 270
dir: disk0/00/00/27/40
datestamp: 2017-12-05 06:27:06
lastmod: 2017-12-05 06:27:06
status_changed: 2017-12-05 06:27:06
type: conference_item
metadata_visibility: show
creators_name: Sherpa, Ang
creators_name: Schossow, Daniel
creators_name: Lenning, Michael
creators_name: Marsh, Paul
creators_name: Garzon, Nick
creators_name: Hofsteen, Peter
creators_name: Cao, Hung
creators_name: Yang, Jingchun
creators_name: Xu, Xiaolei
creators_name: Nguyen, Thi Thanh Van
creators_name: Tran, Nhu Chi
creators_name: Bui, Thanh Tung
creators_name: Chu, Duc Trinh
creators_id: vanntt@vnu.edu.vn
creators_id: trannhuchi@gmail.com
creators_id: tungbt@vnu.edu.vn
creators_id: trinhcd@vnu.edu.vn
title: Novel Apparatus for Simultaneous Monitoring of
Electrocardiogram in Awake Zebrafish
ispublished: pub
subjects: ElectronicsandComputerEngineering
divisions: fac_fet
abstract: This paper reports polymer-based apparatus with embedded flexible thin-film electrodes to monitor electrocardiogram (ECG) of zebrafish under mild or zero anesthesia. The apparatus were made of polydimethylsiloxane(PDMS) using the molding technique with molds formed by 3D printing. The system is capable of acquiring intrinsic ECG from multiple fish simultaneously, thus introducing a novel method to phenotypically assess the hearts’ functionalities, supporting heart regeneration studies, drug screening and other related bio-investigations using the zebrafish model. Smart algorithms were developed to facilitate data processing and analyses. The recorded ECG was compared with that of the same fish under full sedation and a proof-of-concept 4-chamber system was demonstrated. The process does not require a cleanroom, therefore being cost effective and holding promise to accelerate numerous studies in various disciplines using the zebrafish model.
date: 2017-10-30
date_type: published
full_text_status: none
pres_type: poster
pagerange: 1434-1436
event_title: IEEE Sensors 2017
event_location: Glasgow, UK
event_dates: October 30- November 1 2017
event_type: conference
refereed: TRUE
citation:   Sherpa, Ang and Schossow, Daniel and Lenning, Michael and Marsh, Paul and Garzon, Nick and Hofsteen, Peter and Cao, Hung and Yang, Jingchun and Xu, Xiaolei and Nguyen, Thi Thanh Van and Tran, Nhu Chi and Bui, Thanh Tung and Chu, Duc Trinh  (2017) Novel Apparatus for Simultaneous Monitoring of Electrocardiogram in Awake Zebrafish.  In: IEEE Sensors 2017, October 30- November 1 2017, Glasgow, UK.