eprintid: 2885
rev_number: 36
eprint_status: archive
userid: 284
dir: disk0/00/00/28/85
datestamp: 2018-01-09 03:16:07
lastmod: 2018-01-09 03:16:07
status_changed: 2018-01-09 03:16:07
type: article
metadata_visibility: show
creators_name: Endre, J Szili
creators_name: Jun-Seok, Oh
creators_name: Fukuhara, Hideo
creators_name: Rishab, Bhatia
creators_name: Nishtha, Gaur
creators_name: Nguyen, Kien Cuong
creators_name: Sung-Ha, Hong
creators_name: Ito, Satsuki
creators_name: Ogawa, Kotaro
creators_name: Kawada, Chiaki
creators_name: Taro, Shuin
creators_name: Masayuki, Tsuda
creators_name: Furihata, Matsuo
creators_name: Kurabayashi, Atsushi
creators_name: Hiroshi, Furuta
creators_name: Ito, Masafumi
creators_name: Keiji, Inoue
creators_name: Akimitsu, Hatta
creators_name: Robert D, Short
creators_id: Endre.Szili@unisa.edu.au
creators_id: cuongnk@vnu.edu.vn
corp_creators: Future Industries Institute, University of South Australia, Adelaide, SA 5095, Australia
corp_creators: Department of Electronic & Photonic Systems Engineering, Kochi University of Technology, Kami, Kochi 782-8502, Japan
corp_creators: Department of Urology, Kochi Medical School, Nankoku, Kochi, 783-8505, Japan
corp_creators: Faculty of Engineering Physics & Nanotechnology, Vietnam National University, 144 Xuan Thuy, Cau Giay, Hanoi, Vietnam
corp_creators: Division of Laboratory Animal Science section of Life and Functional Materials, Kochi Medical School, Nankoku, Kochi, 783-8505, Japan
corp_creators: Department of Pathology, Kochi Medical School, Kochi Medical School, Nankoku, Kochi, 783-8505, Japan
corp_creators: Materials Science Institute and Department of Chemistry, The University of Lancaster, City of Lancaster LA1 4YW, United Kingdom
title: Modelling the helium plasma jet delivery of
 reactive species into a 3D cancer tumour
ispublished: pub
subjects: Phys
subjects: Scopus
subjects: isi
divisions: fac_physic
abstract: Cold atmospheric plasmas have attracted significant worldwide attention for their potential beneficial effects in cancer therapy. In order to further improve the effectiveness of plasma in cancer therapy, it is important to understand the generation and transport of plasma reactive species into tissue fluids, tissues and cells, and moreover the rates and depths of delivery,
particularly across physical barriers such as skin. In this study, helium (He) plasma jet treatmentof a 3D cancer tumour, grown on the back of a live mouse, induced apoptosis within the tumour to a depth of 2.8 mm. The He plasma jet was shown to deliver reactive oxygen species through the unbroken skin barrier before penetrating through the entire depth of the tumour. The depth
and rate of transport of He plasma jet generated H2O2, NO3− and NO2−, as well as aqueous oxygen [O2(aq)], was then tracked in an agarose tissue model. This provided an approximation of the H2O2, NO3−, NO2− and O2(aq) concentrations that might have been generated during the
He plasma jet treatment of the 3D tumour. It is proposed that the He plasma jet can induce apoptosis within a tumour by the ‘deep’ delivery of H2O2, NO3− and NO2− coupled with O2(aq); the latter raising oxygen tension in hypoxic tissue.

Keywords: tissue oxygenation, tissue model, plasma jet, hypoxia, hyperbaric medicine, reactive
oxygen species (ROS) and reactive nitrogen species (RNS), cancer therapy
date: 2018-01
date_type: published
publisher: IOP Science
official_url: http://iopscience.iop.org/journal/0963-0252
full_text_status: public
publication: Plasma Sources Science and Technology
volume: 27
number: 1
pagerange: 014001-0140016
refereed: TRUE
issn: 0963-0252
related_url_url: http://iopscience.iop.org/issue/0963-0252/27/1
related_url_type: pub
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funders: Australian Government for the travel support for Cuong K. Nguyen through the Endeavour Research Fellowship
citation:   Endre, J Szili and Jun-Seok, Oh and Fukuhara, Hideo and Rishab, Bhatia and Nishtha, Gaur and Nguyen, Kien Cuong and Sung-Ha, Hong and Ito, Satsuki and Ogawa, Kotaro and Kawada, Chiaki and Taro, Shuin and Masayuki, Tsuda and Furihata, Matsuo and Kurabayashi, Atsushi and Hiroshi, Furuta and Ito, Masafumi and Keiji, Inoue and Akimitsu, Hatta and Robert D, Short  (2018) Modelling the helium plasma jet delivery of reactive species into a 3D cancer tumour.  Plasma Sources Science and Technology, 27  (1).   014001-0140016.  ISSN 0963-0252     
document_url: https://eprints.uet.vnu.edu.vn/eprints/id/eprint/2885/1/Szili_2018_Plasma_Sources_Sci._Technol._27_014001.pdf