eprintid: 2972
rev_number: 4
eprint_status: archive
userid: 270
dir: disk0/00/00/29/72
datestamp: 2018-06-08 08:40:05
lastmod: 2018-06-08 08:40:05
status_changed: 2018-06-08 08:40:05
type: article
succeeds: 2734
metadata_visibility: show
creators_name: Vu Quoc, Tuan
creators_name: Wu, Meng-Syuan
creators_name: Bui, Tung Thanh
creators_name: Chu, Duc Trinh
creators_name: Jen, Chun-Ping
creators_id: vqtuan0211@gmail.com
creators_id: Meng-Syuan@gmail.com
creators_id: tungbt@vnu.edu.vn
creators_id: trinhcd@vnu.edu.vn
creators_id: Chun-Ping@gmail.com
title: A compact microfluidic chip with integrated impedance biosensor for protein preconcentration and detection
ispublished: pub
subjects: isi
divisions: fac_fet
abstract: In this study, a low-cost, compact biochip is designed and fabricated for protein detection. Nanofractures formed by self-assembled gold nanoparticles at junction gaps are applied for ion enrichment and depletion to create a trapping zone when electroosmotic flow occurs in microchannels. An impedance measurement module is implemented based on the lock-in amplifier technique to measure the impedance change during antibody growth on the gold electrodes which is caused by trapped proteins in the detection region. The impedance measurement results confirm the presence of trapped proteins. Distinguishable impedance profiles, measured at frequencies in the range of 10–100 kHz, for the detection area taken before and after the presence of proteins validate the performance of the proposed system.
date: 2017-09
date_type: published
publisher: AIP
official_url: http://aip.scitation.org/doi/abs/10.1063/1.4996118
full_text_status: none
publication: Biomicrofluidics
volume: 11
number: 5
pagerange: 054113
refereed: TRUE
issn: 1932-1058
related_url_url: http://aip.scitation.org/doi/abs/10.1063/1.4996118
related_url_type: pub
funders: Nafosted
projects: 107.99-2016.36
citation:   Vu Quoc, Tuan and Wu, Meng-Syuan and Bui, Tung Thanh and Chu, Duc Trinh and Jen, Chun-Ping  (2017) A compact microfluidic chip with integrated impedance biosensor for protein preconcentration and detection.  Biomicrofluidics, 11  (5).   054113.  ISSN 1932-1058