eprintid: 3279
rev_number: 8
eprint_status: archive
userid: 15
dir: disk0/00/00/32/79
datestamp: 2018-12-14 09:58:11
lastmod: 2018-12-14 09:58:11
status_changed: 2018-12-14 09:58:11
type: conference_item
metadata_visibility: show
creators_name: Le, Kim Thu
creators_name: Dang, Cao Cuong
creators_name: Le, Sy Vinh
creators_id: thu.lekim@hust.edu.vn
creators_id: cuongdc@vnu.edu.vn
creators_id: vinhls@vnu.edu.vn
title: Building a specific amino acid substitution model for dengue viruses
ispublished: pub
subjects: IT
divisions: fac_fit
abstract: Phylogenetic trees inferred from protein sequences are strongly affected by amino acid substitution models. Although different amino acid substitution models have been proposed, only a few were estimated for specific species such as the FLU model for influenza viruses. Among the most dangerous viruses for human health, dengue is always on top and the cause of dengue fever up to 100 million people per year. In this study, we built a specific amino acid substitution model for dengue protein sequences, called DEN. The dengue protein sequences were obtained from the NCBI dengue database and the model was estimated using the maximum likelihood method. Experiments showed that the new model DEN helped to build better phylogenetic trees than other existing models. We strongly recommend researchers to use the DEN model for analyzing dengue protein data.
date: 2018-11
date_type: published
full_text_status: public
pres_type: paper
pagerange: 242-246
event_title: 2018 10th International Conference on Knowledge and Systems Engineering (KSE) (KSE'18)
event_dates: 1-3 November 2018
event_type: conference
refereed: TRUE
citation:   Le, Kim Thu and Dang, Cao Cuong and Le, Sy Vinh  (2018) Building a specific amino acid substitution model for dengue viruses.  In: 2018 10th International Conference on Knowledge and Systems Engineering (KSE) (KSE'18), 1-3 November 2018.     
document_url: https://eprints.uet.vnu.edu.vn/eprints/id/eprint/3279/1/1570470372.pdf