eprintid: 3283
rev_number: 14
eprint_status: archive
userid: 277
dir: disk0/00/00/32/83
datestamp: 2018-12-14 10:07:41
lastmod: 2018-12-14 10:07:41
status_changed: 2018-12-14 10:07:41
type: conference_item
metadata_visibility: show
creators_name: Ha, Thi Quyen
creators_id: quyenht@vnu.edu.vn
title: PHÂN TÍCH TRÌNH TỰ GEN MÃ HÓA ĐỘC TỐ TẢ 
CỦA MỘT SỐ CHỦNG VIBRIO CHOLERAE
ispublished: pub
subjects: Phys
divisions: fac_physic
abstract: Vibrio cholerae, the major agent causing cholera, contains more than 200 serotypes based on O antigen. But only two serotypes of O1 and O139 have caused cholera pandemics in the global. The previous studies have shown that cholera toxin gene  have been presented not only in epidemic strains, but also presented in strains of non-O1 / non-O139 serotypes.  Opposite, V. cholerae O1 and O139 strains could also have no toxin gene.
In this papers, we selected the sequences of cholera toxin genes (ctx) from some of  V. cholerae  isolates representing the O1 serotype (the sixth and the seventh cholera pandemic strains) and non-O1 / non-O139 serotypes (strains of  O27, O37 and O105 serotypes), that were isolated in different geographical regions of Asia for analyzing  and comparison to cholera toxin gene of V. cholerae strain in Vietnam. By using MEGA version 6.0 software, the statistical data as well as the phylogenetic trees showed that cholera toxin gene of V. cholerae in Vietnam was different and always form a separate branch comparing to the cholera toxin genes of other strains. This proved that ctx gene of V.cholerae in Vietnam  has  own genetic characteristics comparing  to ctx genes of the strains in other geographic zones.
The results have demonstrated it’s necessary of determining the changes of cholera toxin gene of V.cholerae strains in different geographical areas. This not only provides information for epidemiological surveillance but also provides important data for cholera disease prevention, because of differences in cholera toxin genes can lead to the ability of different anti-cholera toxin immune response during infecting by these pathogenic clones.
date: 2018
date_type: published
full_text_status: public
pres_type: paper
pagerange: 51-58
event_title: Hội nghị Khoa học Công nghệ sinh học toàn quốc 2018
event_location: Hà Nội, Việt Nam
event_dates: 26 October 2018
event_type: conference
refereed: TRUE
citation:   Ha, Thi Quyen  (2018) PHÂN TÍCH TRÌNH TỰ GEN MÃ HÓA ĐỘC TỐ TẢ CỦA MỘT SỐ CHỦNG VIBRIO CHOLERAE.  In: Hội nghị Khoa học Công nghệ sinh học toàn quốc 2018, 26 October 2018, Hà Nội, Việt Nam.     
document_url: https://eprints.uet.vnu.edu.vn/eprints/id/eprint/3283/1/CNSH18-GE_012_Ha-Thi_Quyen%20final.doc