@inproceedings{SisLab3298,
       booktitle = {H?i ngh{\d i} C{\^o}ng ngh? sinh h{\d o}c to{\`a}n qu?c 2018},
           title = {NGHI{\^E}N C?U CH? T{\d A}O NANG CHITOSAN HYDROGEL                                                                                               {\DJ}? {\DJ}{\'O}NG G{\'O}I NANOCURCUMIN},
          author = {Thi Hien Le and Thi Yen Nguyen},
            year = {2018},
             url = {https://eprints.uet.vnu.edu.vn/eprints/id/eprint/3298/},
        abstract = {Chitosan {\dj}ang {\dj}??c nghi{\^e}n c?u l{\`a}m v{\h o} bao nang thu?c thay th? cho gelatin v{\`i} chitosan c{\'o} t{\'i}nh t??ng th{\'i}ch sinh h{\d o}c v{\`a} ph{\^a}n h{\h u}y sinh h{\d o}c v{\`a} c{\'o} th? thay {\dj}?i c?u tr{\'u}c nh? m?t polyme th{\^o}ng minh {\dj}? {\dj}{\'a}p ?ng s? thay {\dj}?i pH ? m{\^o}i tr??ng axit. Trong c{\^o}ng tr{\`i}nh n{\`a}y, chitosan {\dj}??c ch? t{\d a}o d??i d{\d a}ng c?u tr{\'u}c nang hydrogel {\dj}? b{\h a}o v? niosome-curcumin (curcumin trong ch?t mang k{\'i}ch th??c nano) kh{\h o}i m{\^o}i tr??ng axit th?p c{\h u}a d{\d a} d{\`a}y, gi{\'u}p cho niosome-curcumin {\dj}?n {\dj}??c ru?t non. Nang chitosan hydrogel {\dj}??c t{\d a}o ra b?ng ph??ng ph{\'a}p gel h{\'o}a dung d{\d i}ch chitosan nh? ch?t ho{\d a}t {\dj}?ng b? m?t sodium dodecyl sulfate (SDS), sau {\dj}{\'o} lo{\d a}i b{\h o} SDS {\dj}? t{\d a}o nang chitosan hydrogel t??ng th{\'i}ch sinh h{\d o}c. K?t qu{\h a} n{\`a}y {\dj}??c kh?ng {\dj}{\d i}nh b?ng ph??ng ph{\'a}p ph{\^a}n t{\'i}ch ph? h?ng ngo{\d a}i chuy?n {\dj}?i chu?i Fourier (FTIR). Nang chitosan hydrogel t??ng {\dj}?i {\dj}?ng {\dj}?u v?i {\dj}??ng k{\'i}nh ngo{\`a}i kho{\h a}ng 3 mm, kh?i l??ng trung b{\`i}nh kho{\h a}ng 10 mg/h{\d a}t. Qu{\'a} tr{\`i}nh h?p th{\d u} v{\`a} gi{\h a}i ph{\'o}ng d??c ch?t {\dj}??c nghi{\^e}n c?u b?ng ph??ng ph{\'a}p ph? hu{\`y}nh quang v{\`i} curcumin l{\`a} ch?t hu{\`y}nh quang. M??i nang chitosan hydrogel h?p th{\d u} {\dj}??c 4,67 mg niosome-curcumin (t??ng {\dj}??ng v?i 30 microgram curcumin). Nang chitosan hydrogel b{\h a}o v? niosome-curcumin t{\d a}i pH 1,5 v{\`a} gi{\h a}i ph{\'o}ng {\dj}??c kho{\h a}ng 5\% curcumin ? gi{\'a} tr{\d i} pH 1,5 sau hai gi?.}
}