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primary topic: Dielectrophoresis Microfluidic Enrichment Platform with Built-In Capacitive Sensor for Rare Tumor Cell Detection

Dielectrophoresis Microfluidic Enrichment Platform with Built-In Capacitive Sensor for Rare Tumor Cell Detection
type: AcademicArticle
type: Article
abstract: The manipulation and detection of rare cells are important for many applications in early disease diagnosis and medicine. This study presents a dielectrophoresis (DEP) microfluidic enrichment platform combined with a built-in capacitive sensor for circulating tumor cell detection. The microchip is composed of a lollipop-shaped gold microelectrode structure under a polydimethylsiloxane chamber. A prototype of the device was fabricated using standard micromachining technology. With the proposed device, target cells (in this study, A549 non-small human lung carcinoma and S-180 sarcoma cell lines) are firstly guided toward the center of the working chamber via DEP forces. Then, the target cells are captured by an electrode immobilized by anti-EGFR, which has high affinity toward the target cells. After the cell concentration process, the differential capacitance is read to detect the presence of the target cells. Numerical simulations and measurement experiments were performed to demonstrate the high sensitivity of differential capacitive sensing. The obtained results show high sensitivity for S-180 cell detection (3 mV/cell). The proposed platform is suitable for rapid cancer diagnoses and other metabolic disease applications.
date: 2018-06
volume: 12
issue: 2
is part of: BioChip Journal
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: ISI-indexed journals

BioChip Journal
type: Collection
issn: 19760280

Duc Trinh Chu
type: Person
given name: Duc Trinh
family name: Chu

Van Thanh Dau
type: Person
given name: Van Thanh
family name: Dau

Thi Thuy Ha Tran
type: Person
given name: Thi Thuy Ha
family name: Tran

Loc Quang Do
type: Person
given name: Loc Quang
family name: Do

Thanh Tung Bui
type: Person
given name: Thanh Tung
family name: Bui

Ngoc Viet Nguyen
type: Person
given name: Ngoc Viet
family name: Nguyen

Chun-Ping Jen
type: Person
given name: Chun-Ping
family name: Jen

HTML Summary of #3307 Dielectrophoresis Microfluidic Enrichment Platform with Built-In Capacitive Sensor for Rare Tumor Cell Detection
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primary topic: Dielectrophoresis Microfluidic Enrichment Platform with Built-In Capacitive Sensor for Rare Tumor Cell Detection

ISI-indexed journals
type: Concept