eprintid: 4139
rev_number: 7
eprint_status: archive
userid: 270
dir: disk0/00/00/41/39
datestamp: 2020-12-08 09:28:55
lastmod: 2020-12-08 09:29:17
status_changed: 2020-12-08 09:28:55
type: article
metadata_visibility: show
creators_name: Do, Loc Quang
creators_name: Bui, Thanh Tung
creators_name: Hoang, Bao Anh
creators_name: Nguyen, Nhu Cuong
creators_name: Tran, Thi Thuy Ha
creators_name: Jen, Chun-Ping
creators_name: Chu, Duc Trinh
creators_id: locdq@hus.edu.vn
creators_id: tungbt@vnu.edu.vn
creators_id: anhbh@vnu.edu.vn
creators_id: cuongnn241@gmail.com
creators_id: tttha@gmail.com
creators_id: Chun-Ping@gmail.com
creators_id: trinhcd@vnu.edu.vn
title: Biological living cell in-flow detection based on microfluidic chip and compact signal processing circuit
ispublished: pub
subjects: ElectronicsandComputerEngineering
subjects: isi_scopus_conf
divisions: cetr_uet
divisions: fac_fet
abstract: Detection and enumeration of biological living cells in continuous fluidic flows play an essential role in many applications for early diagnosis and treatment of diseases. In this regard, this study highlighted the proposal of a biochip system for detecting and enumerating human lung carcinoma cell flow in the microfluidic channel. The principle of detection was based on the change of impedance between sensing electrodes integrated in the fluidic channel, due to the presence of a biological cell in the sensing region. A compact electronic module was built to sense the unbalanced impedance between the sensing microelectrodes. It consisted of an instrumentation amplifier stage to obtain the difference between the acquired signals, and a lock-in amplifier stage to demodulate the signals at the stimulating frequency as well as to reject noise at other frequencies. The performance of the proposed system was validated through experiments of A549 cells detection as they passed over the microfluidic channel. The experimental results indicated the occurrence of large spikes (up to approximately 180 mV) over the background signal according to the passage of a single A549 cell in the continuous flow. The proposed device is simple-to-operate, inexpensive, portable, and exhibits high sensitivity, which are suitable considerations for developing point-of-care applications.
date: 2020-10
date_type: published
official_url: http://dx.doi.org/10.1109/TBCAS.2020.3030017
id_number: 10.1109/TBCAS.2020.3030017
full_text_status: none
publication: IEEE Transactions on Biomedical Circuits and Systems
pagerange: 1-1
refereed: TRUE
issn: 1932-4545
citation:   Do, Loc Quang and Bui, Thanh Tung and Hoang, Bao Anh and Nguyen, Nhu Cuong and Tran, Thi Thuy Ha and Jen, Chun-Ping and Chu, Duc Trinh  (2020) Biological living cell in-flow detection based on microfluidic chip and compact signal processing circuit.  IEEE Transactions on Biomedical Circuits and Systems .   p. 1.  ISSN 1932-4545