eprintid: 4533
rev_number: 6
eprint_status: archive
userid: 15
dir: disk0/00/00/45/33
datestamp: 2021-06-28 02:33:18
lastmod: 2021-06-28 02:33:18
status_changed: 2021-06-28 02:33:18
type: article
succeeds: 4531
metadata_visibility: show
creators_name: Minh, Bui Quang
creators_name: Dang, Cao Cuong
creators_name: Vinh, Le Sy
creators_name: Lanfear, Robert
creators_id: m.bui@anu.edu.au
creators_id: cuongdc@vnu.edu.vn
creators_id: vinhls@vnu.edu.vn
creators_id: rob.lanfear@anu.edu.au
title: QMaker: Fast and Accurate Method to Estimate Empirical Models of Protein Evolution
ispublished: pub
subjects: IT
subjects: isi
divisions: fac_fit
abstract: Amino acid substitution models play a crucial role in phylogenetic analyses. Maximum likelihood (ML) methods have been proposed to estimate amino acid substitution models; however, they are typically complicated and slow. In this article, we propose QMaker, a new ML method to estimate a general time-reversible Q matrix from a large protein data set consisting of multiple sequence alignments. QMaker combines an efficient ML tree search algorithm, a model selection for handling the model heterogeneity among alignments, and the consideration of rate mixture models among sites. We provide QMaker as a user-friendly function in the IQ-TREE software package (http://www.iqtree.org) supporting the use of multiple CPU cores so that biologists can easily estimate amino acid substitution models from their own protein alignments. We used QMaker to estimate new empirical general amino acid substitution models from the current Pfam database as well as five clade-specific models for mammals, birds, insects, yeasts, and plants. Our results show that the new models considerably improve the fit between model and data and in some cases influence the inference of phylogenetic tree topologies.[Amino acid replacement matrices; amino acid substitution models; maximum likelihood estimation; phylogenetic inferences.
date: 2021-02-22
date_type: published
publisher: Oxford University Press
official_url: http://dx.doi.org/10.1093/sysbio/syab010
id_number: 10.1093/sysbio/syab010
full_text_status: public
publication: Systematic Biology
refereed: TRUE
issn: 1063-5157
citation:   Minh, Bui Quang and Dang, Cao Cuong and Vinh, Le Sy and Lanfear, Robert  (2021) QMaker: Fast and Accurate Method to Estimate Empirical Models of Protein Evolution.  Systematic Biology .    ISSN 1063-5157     
document_url: https://eprints.uet.vnu.edu.vn/eprints/id/eprint/4533/1/syab010.pdf