TY  - CONF
ID  - SisLab71
UR  - https://eprints.uet.vnu.edu.vn/eprints/id/eprint/71/
A1  - Nguyen, Van Sau
A1  - Dang, Cao Cuong
A1  - Le, Si Quang
A1  - Le, Sy Vinh
Y1  - 2011/10//
N2  - The amino acid substitution model (matrix) is a crucial part of protein sequence analysis systems. General amino acid substitution models have been estimated from large protein databases, however, they are not specific for influenza viruses. In previous study, we estimated the amino acid substitution model, FLU, for all influenza viruses. Experiments showed that FLU outperformed other models when analyzing influenza protein sequences. Influenza virus genomes consist of different protein types, which are different in both structures and evolutionary processes. Although FLU matrix is specific for influenza viruses, it is still not specific for influenza protein types. Since influenza viruses cause serious problems for both human health and social economics, it is worth to study them as specific as possible. In this paper, we used more than 27 million amino acids to estimate 11 protein type specific models for influenza viruses. Experiments showed that protein type specific models outperformed the FLU model, the best model for influenza viruses. These protein type specific models help researcher to conduct studies on influenza viruses more precisely.
KW  - biology computing
KW  -  diseases
KW  -  FLU model
KW  -  human health
KW  -  influenza virus genomes
KW  -  microorganisms
KW  -  protein databases
KW  -  protein sequence analysis systems
KW  -  protein type specific amino acid substitution models
KW  -  Proteins
KW  -  social economics
TI  - Protein Type Specific Amino Acid Substitution Models for Influenza Viruses
SP  - 98 
AV  - none
EP  - 103
T2  - 2011 Third International Conference on Knowledge and Systems Engineering (KSE)
ER  -