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Detection of magnetically labeled DNA by a magnetic sensor operating with a disposable card

Le, Thi Hien and Le, Khac Quynh and Vu, Thi Huyen and Nguyen, Thi Yen and Bui, Dinh Tu and Pham, Hong Nhung and Do, Thi Huong Giang and Nguyen, Huu Duc (2016) Detection of magnetically labeled DNA by a magnetic sensor operating with a disposable card. In: International Workshop on Advanced Materials and Nanotechnology 2016 (IWAMN 2016), 3-5 November 2016, Hanoi, Vietnam.

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Disposable cards with immobilized bioreceptors are being increasingly investigated and developed in biomedical analysis systems because they have significant advantages. In our work, a biosensor system consisting of an anisotropic magnetoresistive (AMR) sensor operating with a disposable card was developed for magnetically labeled DNA detection. The SPA/SAA/APTES/PDMS/Si as-prepared disposable card involves DNA probes specific for the 16S rRNA gene of Streptococcus suis. A single-stranded target DNA was hybridized with the DNA probe on the disposable card, which was subsequently magnetically labeled with superparamagnetic beads for detection using the AMR sensor. An almost linear response between the output signal of the AMR sensor and amount of single-stranded target DNA varied from 4.5 to 18 pmol was identified. This novel approach opens up new possibilities for the development of a sensitive, easy to use and low-cost DNA biosensor system.

Item Type: Conference or Workshop Item (Speech)
Subjects: Engineering Physics
Divisions: Faculty of Engineering Physics and Nanotechnology (FEPN)
Depositing User: Hien Thi Le
Date Deposited: 31 Dec 2016 10:18
Last Modified: 31 Dec 2016 10:18

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