Modelling the helium plasma jet delivery of reactive species into a 3D cancer tumour

Endre, J Szili and Jun-Seok, Oh and Fukuhara, Hideo and Rishab, Bhatia and Nishtha, Gaur and Nguyen, Kien Cuong and Sung-Ha, Hong and Ito, Satsuki and Ogawa, Kotaro and Kawada, Chiaki and Taro, Shuin and Masayuki, Tsuda and Furihata, Matsuo and Kurabayashi, Atsushi and Hiroshi, Furuta and Ito, Masafumi and Keiji, Inoue and Akimitsu, Hatta and Robert D, Short (2018) Modelling the helium plasma jet delivery of reactive species into a 3D cancer tumour. Plasma Sources Science and Technology, 27 (1). 014001-0140016. ISSN 0963-0252

PDF - Published Version Download (3MB)

Abstract

Cold atmospheric plasmas have attracted significant worldwide attention for their potential beneficial effects in cancer therapy. In order to further improve the effectiveness of plasma in cancer therapy, it is important to understand the generation and transport of plasma reactive species into tissue fluids, tissues and cells, and moreover the rates and depths of delivery, particularly across physical barriers such as skin. In this study, helium (He) plasma jet treatmentof a 3D cancer tumour, grown on the back of a live mouse, induced apoptosis within the tumour to a depth of 2.8 mm. The He plasma jet was shown to deliver reactive oxygen species through the unbroken skin barrier before penetrating through the entire depth of the tumour. The depth and rate of transport of He plasma jet generated H2O2, NO3− and NO2−, as well as aqueous oxygen [O2(aq)], was then tracked in an agarose tissue model. This provided an approximation of the H2O2, NO3−, NO2− and O2(aq) concentrations that might have been generated during the He plasma jet treatment of the 3D tumour. It is proposed that the He plasma jet can induce apoptosis within a tumour by the ‘deep’ delivery of H2O2, NO3− and NO2− coupled with O2(aq); the latter raising oxygen tension in hypoxic tissue. Keywords: tissue oxygenation, tissue model, plasma jet, hypoxia, hyperbaric medicine, reactive oxygen species (ROS) and reactive nitrogen species (RNS), cancer therapy

Item Type:	Article
Subjects:	Engineering Physics Scopus-indexed journals ISI-indexed journals
Divisions:	Faculty of Engineering Physics and Nanotechnology (FEPN)
Depositing User:	Assoc.Prof Cuong / Kien NGUYEN
Date Deposited:	09 Jan 2018 03:16
Last Modified:	09 Jan 2018 03:16
URI:	http://eprints.uet.vnu.edu.vn/eprints/id/eprint/2885

Actions (login required)

View Item