A compact microfluidic chip with integrated impedance biosensor for protein preconcentration and detection

Vu Quoc, Tuan and Wu, Meng-Syuan and Bui, Tung Thanh and Chu, Duc Trinh and Jen, Chun-Ping (2017) A compact microfluidic chip with integrated impedance biosensor for protein preconcentration and detection. Biomicrofluidics, 11 (5). 054113. ISSN 1932-1058

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Abstract

In this study, a low-cost, compact biochip is designed and fabricated for protein detection. Nanofractures formed by self-assembled gold nanoparticles at junction gaps are applied for ion enrichment and depletion to create a trapping zone when electroosmotic flow occurs in microchannels. An impedance measurement module is implemented based on the lock-in amplifier technique to measure the impedance change during antibody growth on the gold electrodes which is caused by trapped proteins in the detection region. The impedance measurement results confirm the presence of trapped proteins. Distinguishable impedance profiles, measured at frequencies in the range of 10–100 kHz, for the detection area taken before and after the presence of proteins validate the performance of the proposed system.

Item Type:	Article
Subjects:	ISI-indexed journals
Divisions:	Faculty of Electronics and Telecommunications (FET)
Depositing User:	Bùi Thanh Tùng
Date Deposited:	08 Jun 2018 08:40
Last Modified:	08 Jun 2018 08:40
URI:	http://eprints.uet.vnu.edu.vn/eprints/id/eprint/2972

Available Versions of this Item

• A compact microfluidic chip with integrated impedance biosensor for protein preconcentration and detection. (deposited 03 Dec 2017 11:22)
  • A compact microfluidic chip with integrated impedance biosensor for protein preconcentration and detection. (deposited 04 Dec 2017 02:57)
    • A compact microfluidic chip with integrated impedance biosensor for protein preconcentration and detection. (deposited 08 Jun 2018 08:40) [Currently Displayed]

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