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Novel Apparatus for Simultaneous Monitoring of Electrocardiogram in Awake Zebrafish

Nguyen, Thi Thanh Van and Tran, Nhu Chi and Bui, Thanh Tung and Chu, Duc Trinh and Sherpa, Ang and Lenning, Michael and Marsh, Paul and Garzon, Nick and Hofsteen, Peter and Cao, Hung and Yang, Jingchun and Xu, Xiaolei (2017) Novel Apparatus for Simultaneous Monitoring of Electrocardiogram in Awake Zebrafish. In: IEEE Sensors 2017, 30 October 2017 - 1 November 2017, Glasgow, Scotland, UK.

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This paper reports polymer-based apparatus with embedded flexible thin-film electrodes to monitor electrocardiogram (ECG) of zebrafish under mild or zero anesthesia. The apparatus were made of polydimethylsiloxane (PDMS) using the molding technique with molds formed by 3D printing. The system is capable of acquiring intrinsic ECG from multiple fish simultaneously, thus introducing a novel method to phenotypically assess the hearts’ functionalities, supporting heart regeneration studies, drug screening and other related bioinvestigations using the zebrafish model. Smart algorithms were developed to facilitate data processing and analyses. The recorded ECG was compared with that of the same fish under full sedation and a proof-of-concept 4-chamber system was demonstrated. The process does not require a cleanroom, therefore being cost effective and holding promise to accelerate numerous studies in various disciplines using the zebrafish model

Item Type: Conference or Workshop Item (Paper)
Additional Information:
Subjects: Electronics and Communications
Electronics and Communications > Electronics and Computer Engineering
Divisions: Faculty of Electronics and Telecommunications (FET)
Depositing User: Trần Như Chí
Date Deposited: 17 Dec 2018 03:58
Last Modified: 17 Dec 2018 03:58

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