Ha, Thi Quyen (2018) PHÂN TÍCH TRÌNH TỰ GEN MÃ HÓA ĐỘC TỐ TẢ CỦA MỘT SỐ CHỦNG VIBRIO CHOLERAE. In: Hội nghị Khoa học Công nghệ sinh học toàn quốc 2018, 26 October 2018, Hà Nội, Việt Nam.
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Abstract
Vibrio cholerae, the major agent causing cholera, contains more than 200 serotypes based on O antigen. But only two serotypes of O1 and O139 have caused cholera pandemics in the global. The previous studies have shown that cholera toxin gene have been presented not only in epidemic strains, but also presented in strains of non-O1 / non-O139 serotypes. Opposite, V. cholerae O1 and O139 strains could also have no toxin gene. In this papers, we selected the sequences of cholera toxin genes (ctx) from some of V. cholerae isolates representing the O1 serotype (the sixth and the seventh cholera pandemic strains) and non-O1 / non-O139 serotypes (strains of O27, O37 and O105 serotypes), that were isolated in different geographical regions of Asia for analyzing and comparison to cholera toxin gene of V. cholerae strain in Vietnam. By using MEGA version 6.0 software, the statistical data as well as the phylogenetic trees showed that cholera toxin gene of V. cholerae in Vietnam was different and always form a separate branch comparing to the cholera toxin genes of other strains. This proved that ctx gene of V.cholerae in Vietnam has own genetic characteristics comparing to ctx genes of the strains in other geographic zones. The results have demonstrated it’s necessary of determining the changes of cholera toxin gene of V.cholerae strains in different geographical areas. This not only provides information for epidemiological surveillance but also provides important data for cholera disease prevention, because of differences in cholera toxin genes can lead to the ability of different anti-cholera toxin immune response during infecting by these pathogenic clones.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | Engineering Physics |
| Divisions: | Faculty of Engineering Physics and Nanotechnology (FEPN) |
| Depositing User: | Hà Th� Quyến |
| Date Deposited: | 14 Dec 2018 10:07 |
| Last Modified: | 14 Dec 2018 10:07 |
| URI: | http://eprints.uet.vnu.edu.vn/eprints/id/eprint/3283 |
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