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Automatic scan range for dose-reduced multiphase CT imaging of the liver utilizing CNNs and Gaussian models

Luu, Manh Ha and Walsum, Theo van and Mai, Hong Son and Franklin, Daniel and Nguyen, Thi Thu Thao and Le, Thi My and Moelker, Adraan and Le, Van Khang and Vu, Dang Luu and Le, Ngoc Ha and Tran, Quoc Long and Chu, Duc Trinh and Nguyen, Linh Trung (2022) Automatic scan range for dose-reduced multiphase CT imaging of the liver utilizing CNNs and Gaussian models. Medical Image Analysis .

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Multiphase CT scanning of the liver is performed for several clinical applications; however, radiation exposure from CT scanning poses a nontrivial cancer risk to the patients. The radiation dose may be reduced by determining the scan range of the subsequent scans by the location of the target of interest in the first scan phase. The purpose of this study is to present and assess an automatic method for determining the scan range for multiphase CT scans. Our strategy is to first apply a CNN-based method for detecting the liver in 2D slices, and to use a liver range search algorithm for detecting the liver range in the scout volume. The target liver scan range for subsequent scans can be obtained by adding safety margins achieved from Gaussian liver motion models to the scan range determined from the scout. Experiments were performed on 657 multiphase CT volumes obtained from multiple hospitals. The experiment shows that the proposed liver detection method can detect the liver in 223 out of a total of 224 3D volumes on average within one second, with mean intersection of union, wall distance and centroid distance of 85.5%, 5.7 mm and 9.7 mm, respectively. In addition, the performance of the proposed liver detection method is comparable to the best of the state-of-the-art 3D liver detectors in the liver detection accuracy while it requires less processing time. Furthermore, we apply the liver scan range generation method on the liver CT images acquired from radiofrequency ablation and Y-90 transarterial radioembolization (selective internal radiation therapy) interventions of 46 patients from two hospitals. The result shows that the automatic scan range generation can significantly reduce the effective radiation dose by an average of 14.5% (2.56 mSv) compared to manual performance by the radiographer from Y-90 transarterial radioembolization, while no statistically significant difference in performance was found with the CT images from intra RFA intervention ( = 0.81). Finally, three radiologists assess both the original and the range-reduced images for evaluating the effect of the range reduction method on their clinical decisions. We conclude that the automatic liver scan range generation method is able to reduce excess radiation compared to the manual performance with a high accuracy and without penalizing the clinical decision.

Item Type: Article
Subjects: Electronics and Communications > Electronics and Computer Engineering
Information Technology (IT)
ISI-indexed journals
Divisions: Advanced Insitute of Engineering and Technology (AVITECH)
Faculty of Electronics and Telecommunications (FET)
Faculty of Information Technology (FIT)
Depositing User: Lưu Mạnh Hà
Date Deposited: 22 Aug 2022 04:06
Last Modified: 22 Aug 2022 04:06

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