Do, Loc Quang and Tran, Thi Thuy Ha and Bui, Thanh Tung and Dau, Van Thanh and Nguyen, Ngoc Viet and Chu, Duc Trinh and Jen, Chun-Ping (2018) Dielectrophoresis Microfluidic Enrichment Platform with Built-In Capacitive Sensor for Rare Tumor Cell Detection. BioChip Journal, 12 (2). pp. 114-122. ISSN 1976-0280
Full text not available from this repository.Abstract
The manipulation and detection of rare cells are important for many applications in early disease diagnosis and medicine. This study presents a dielectrophoresis (DEP) microfluidic enrichment platform combined with a built-in capacitive sensor for circulating tumor cell detection. The microchip is composed of a lollipop-shaped gold microelectrode structure under a polydimethylsiloxane chamber. A prototype of the device was fabricated using standard micromachining technology. With the proposed device, target cells (in this study, A549 non-small human lung carcinoma and S-180 sarcoma cell lines) are firstly guided toward the center of the working chamber via DEP forces. Then, the target cells are captured by an electrode immobilized by anti-EGFR, which has high affinity toward the target cells. After the cell concentration process, the differential capacitance is read to detect the presence of the target cells. Numerical simulations and measurement experiments were performed to demonstrate the high sensitivity of differential capacitive sensing. The obtained results show high sensitivity for S-180 cell detection (3 mV/cell). The proposed platform is suitable for rapid cancer diagnoses and other metabolic disease applications.
| Item Type: | Article |
|---|---|
| Subjects: | ISI-indexed journals |
| Divisions: | Center for Electronics and Telecommunications Research (CETR) Faculty of Electronics and Telecommunications (FET) |
| Depositing User: | Bùi Thanh Tùng |
| Date Deposited: | 09 Dec 2019 03:31 |
| Last Modified: | 09 Dec 2019 03:31 |
| URI: | http://eprints.uet.vnu.edu.vn/eprints/id/eprint/3307 |
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